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Vitamins and Minerals
May Reduce Bladder Cancer Risk

More Evidence About How Antioxidants, Carotenoids and
Minerals-Vitamins Support Cancer Risk reduction

Increased intakes of vitamin E may reduce the risk of bladder cancer
by about 35 per cent, says a new study from an international team of researchers.

Findings published in Cancer Causes and Control also showed that carotenoids,
niacin, thiamine, and vitamin D may reduce the risk of bladder cancer in older people.

“The effects of vitamin E, carotenoids, vitamin D, thiamin, and niacin in relation to
the risk of developing bladder cancer may warrant further investigation,” report the
researchers from The Cancer Council Victoria in Australia.

“Future studies should focus on optimal doses and combinations of these
micronutrients particularly for high risk groups such as heavy smokers and older
individuals,” they state.

Bladder cancer is diagnosed in about 336,000 people every year worldwide, and
it is three times more likely to affect men than women, according to the European
School of Oncology.

The researchers analysed dietary data from 322 people with bladder cancer and
239 healthy controls.
A comprehensive food frequency questionnaire was used to
estimate dietary intakes.

Results showed that, in general, people with the highest average daily intakes
of vitamin E were 34 per cent less likely to develop bladder cancer. The highest
average intakes of phosphorous were associated with a 51 per cent reduction
in bladder cancer risk.

When the researchers focused their analysis on smokers, they found that the
highest intakes of vitamin E, carotenoids (18 milligrams), and niacin (46.5
milligrams), were associated with a 42, 38, and 34 per cent reduction in
bladder cancer risk in heavy smokers.

In older individuals, the highest average intakes of carotenoids, vitamin D
(641 IU), thiamin (3.35 milligrams),
niacin, and vitamin E were all associated
with a reduced bladder cancer risk.

“Bladder cancer is a disease that typically affects older people, and
bioavailability of B-group vitamins may be compromised in this demographic
by certain drugs (such as acid lowering medicines),” stated the researchers.
“Additionally, vitamin E, like carotenoids acts as an antioxidant and, as
suggested by our results, could be more beneficial under conditions of the
greatest oxidative stress such as smoking and ageing.”

The researchers recommended additional study to further examine these
potentially protective relationships.

The study was supported by the National Institute of Environmental Health
Sciences and the National Cancer Institute at the US National Institutes of
Health (NIH).

Source: Cancer Causes and Control
Published online:
“Minerals and vitamins and the risk of bladder cancer:
results from the New Hampshire Study”

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