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Soy Isoflavones May
Modify Risk of Breast Cancer

Increased intake of phyto-estrogens commonly found
in dietary soy may modify the risk of some types of
breast cancer, according to findings presented at the
Ninth Annual AACR Frontiers in Cancer Prevention
Research Conference, held in Philadelphia.

“This study was unique in that we looked at specific
subtypes of breast cancer, and found a suggestion that
menopausal status may play a role in risk,” said researchers
from the University at Buffalo and research apprentice at
Roswell Park Cancer Institute.

The research team evaluated 683 women with breast
cancer and compared them with 611 healthy women.
Dietary data patterns were observed using a food frequency
questionnaire and isoflavones were measured as a dietary,
rather than supplemental, intake. Isoflavone intake was
divided into three groups.

Those women with the highest isoflavone intake had an
approximately 30 percent decreased risk of having an
invasive breast tumor, and an approximately 60 percent
decreased risk of having a grade 1 tumor.

Observations by menopausal status revealed the following:
Among premenopausal women, the highest intake of
isoflavones had a 30 percent decreased risk of stage 1
disease, a 70 percent decreased risk of having a tumor larger
than 2 cm, and a 60 percent decreased risk of having stage 2
breast cancer. These connections were not seen among
postmenopausal women.

These findings are not definitive and need to be considered
in the context of further follow-up and confirmation.

“Still, we definitely saw a reduction that deserves further
investigation,” they said.

Story Source:
American Association for Cancer Research
(2010, November 9)
“Soy isoflavones may modify risk of breast cancer”

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